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Led by Zoe Lee, who goes by Purple, the six-person Team Erie Canal stops terrorism and common crimes in the city of Toledo with help from their "mutations manifest," superhuman powers developed by the mysterious Department.
But shortly after their sophomore year begins, the teens gain six more teammates, members of their freshman class.
Soon, the six senior heroes face problems in their friendships that they have never encountered. As the team proceeds to their unavoidable brush with terrorist group Omega Ark, lines are drawn, friendships fail - and in the end, one of the twelve will betray the team, and one of them won't make it out alive.